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Prof. Søren W. Gersting

Søren W. Gersting, MD, is Professor of Pediatric Research at Kinder-UKE, University Children’s Hospital based at University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

 

Prof. Gersting obtained his MD degree at the Ludwig-Maximilians-University in Munich, Germany in 2002. After completing an MD thesis project on gene therapy in cystic fibrosis and a one-year internship at the University Children’s Hospital in Munich, Germany, he received post-doctoral training in the Department of Molecular Pediatrics at the Dr. von Hauner Children’s Hospital, Munich, Germany. In 2006, Prof. Gersting took there the position as Head of Laboratory.

 

His research in the Department of Molecular Pediatrics, which was headed by Prof. Ania C Muntau, first focused on the structural mechanisms of protein misfolding and loss of function in inborn errors of metabolism. Prof. Gersting and Prof. Muntau showed how amino acid side chain substitutions due to genetic variation lead to structural derangement and reduced stability of affected proteins. Their work contributed to a mechanistic understanding of cofactor treatment in phenylketonuria (PKU), which is efficient in a significant share of patients suffering from this inborn error of amino acid metabolism. In 2014, Prof. Gersting was assigned head of the Department of Molecular Pediatrics. In a joint academic-industrial project, his group identified novel drug candidates for the treatment of inborn errors of metabolism associated with protein misfolding.

 

Prof. Gersting was appointed Full Professor at the University Children’s Hospital in Hamburg, Germany in 2018. As Head of Pediatric Research at Kinder-UKE, he continues his translational research for the treatment of children suffering from inborn errors of metabolism.

 

Prof. Gersting has (co-)authored 30 peer-reviewed publications in the field of inborn errors of metabolism and PKU.